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A complex five breakpoint intrachromosomal rearrangement ascertained through two recombinant offspring
C M Tuck-Muller1, M Varela, S Li
1Department of Medical Genetics, University of South Alabama, Mobile 36688-0002, USA.
American Journal of Medical Genetics
|May 17, 1996
Summary
A rare, complex chromosome 10 rearrangement involving five breaks was identified in a phenotypically normal father. His children inherited a recombinant chromosome 10, leading to developmental delays.
Area of Science:
- Human Genetics
- Molecular Biology
- Cytogenetics
Background:
- Intrachromosomal rearrangements are typically caused by three or fewer chromosomal breaks.
- Complex chromosomal rearrangements can lead to genetic disorders and developmental abnormalities.