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Local recurrence and survival in soft-tissue sarcomas
C P Karakousis1, C Proimakis, U Rao
1Millard Fillmore Hospitals, State University of New York, Buffalo 14209, USA.
Annals of Surgical Oncology
|May 1, 1996
Summary
Local recurrence of soft-tissue sarcoma is treatable, with limb preservation achieved in most cases. Tumor grade and size significantly impact survival rates after treatment.
Area of Science:
- Oncology
- Surgical Oncology
- Sarcoma Research
Background:
- Local recurrence is a frequent challenge in soft-tissue sarcoma management.
- Effective treatment strategies and survival outcomes for recurrent sarcomas are of significant clinical interest.
Purpose of the Study:
- To evaluate prognostic factors influencing survival after treatment for local recurrence of soft-tissue sarcoma.
- To assess the efficacy of surgical resection and limb preservation in managing recurrent soft-tissue sarcomas.
Main Methods:
- Retrospective review of 93 patients with local recurrence of soft-tissue sarcoma.
- Analysis of prognostic parameters including tumor grade, size, and location.
- Evaluation of treatment outcomes, focusing on resection rates, limb preservation, and survival.
Main Results:
- Complete tumor resection was achieved in 95% of patients.
- Limb amputation was necessary in 10% of extremity tumor cases.
- Five-year survival rates were 100% for grade I, 77% for grade II, and 45% for grade III tumors (p=0.0002). Survival was 78% for tumors ≤5 cm and 57% for tumors >5 cm (p=0.03).
Conclusions:
- Local recurrence of soft-tissue sarcoma is manageable with surgical resection, and limb preservation is feasible for most patients.
- Overall five-year survival after treatment for local recurrence was 65%.
- Tumor grade and size are critical determinants of survival, similar to primary sarcomas.