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Mortality in patients with Crohn's disease
M Cottone1, A Magliocco, M Rosselli
1Istituto di Clinica Medica R, Ospedale V. Cervello, Palermo, Italy.
Scandinavian Journal of Gastroenterology
|April 1, 1996
Summary
Mortality for Crohn's disease in southern Europe was studied. The standardized mortality rate (SMR) was 0.97, indicating no increased risk overall, but higher risk for females in the first 5 years post-diagnosis.
Area of Science:
- Gastroenterology
- Epidemiology
- Public Health
Background:
- Limited data exists on Crohn's disease mortality in Southern Europe.
- This study addresses the gap in understanding Crohn's disease outcomes in this region.
Purpose of the Study:
- To determine the mortality rate of Crohn's disease patients in Southern Europe.
- To identify any specific risk factors or demographic groups with altered mortality.
Main Methods:
- A consecutive incidence series of 531 Crohn's disease patients observed between 1973 and 1993.
- Standardized Mortality Rate (SMR) calculated with 99% follow-up completeness.
Main Results:
- Observed deaths (9) were close to expected (9.25), yielding an SMR of 0.97 (95% CI, 0.4-1.8).
- Females showed a significantly higher relative risk of death within 5 years of diagnosis (SMR, 10.3; 95% CI, 2.30-30.2).
- An excess of deaths from digestive organ tumors was noted (1 observed vs. 0.37 expected).
Conclusions:
- Mortality from Crohn's disease in this Southern European region is not elevated compared to general population rates.
- Specific attention to female patients in the early years post-diagnosis is warranted.
- Further investigation into the observed excess of digestive organ tumors is recommended.