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Myocardial infarction associated with thyrotoxicosis

A J Proskey, F Saksena, W D Towne

    Chest
    |July 1, 1977
    PubMed
    Summary

    Thyrotoxicosis can rarely cause myocardial infarction (heart attack) even without coronary artery disease. This suggests thyroid hormone directly impacts heart oxygen balance, leading to cardiac events.

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    Area of Science:

    • Cardiology
    • Endocrinology

    Background:

    • Thyrotoxicosis, a condition of excess thyroid hormone, is a rare cause of myocardial infarction.
    • Understanding the mechanisms linking thyroid dysfunction to cardiac events is crucial for patient management.

    Observation:

    • A 34-year-old woman with thyrotoxicosis experienced a transmural myocardial infarction.
    • Cardiac catheterization revealed no significant coronary arterial disease, only apical wall akinesia.

    Findings:

    • Thyroid hormone may directly affect myocardial oxygen supply and demand.
    • An imbalance, independent of major coronary artery blockages, can precipitate angina and myocardial infarction.

    Implications:

    • This case highlights a potential direct cardiotoxic effect of thyroid hormone.
    • Further research is needed to elucidate the specific mechanisms involved in thyrotoxicosis-induced myocardial infarction.

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