Related Experiment Videos
The effect of 1,24(R)(OH)2D3 cream and ointment on epidermal proliferation and differentiation in mice
H Sato1, I Sugimoto, M Fukuoka
1Pharmacological Research Department, Teijin Institute for Bio-Medical Research, Tokyo, Japan.
Background:
The 1,24(R)(OH)2D3 (tacalcitol) ointment (2 micrograms/g) is available commercially as an antipsoriatic drug in Japan, but the cream preparation of tacalcitol is still under development.
Objective:
This study was conducted to compare the ability of tacalcitol cream and ointment to inhibit epidermal proliferation and induce epidermal differentiation.
Methods:
We measured the ornithine decarboxylase activity and type I transglutaminase activity as indices of proliferation and differentiation, respectively, in hairless mice.
Results:
These effects were statistically equal to those of the ointment preparation at the same dose, 2 micrograms/g, without inducing hypercalcemia.
Conclusions:
These findings suggest that topical application of 1,24(OH)2D3 cream (2 micrograms/g) might have the same potency as the ointment formulation in the treatment of psoriasis.