Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronotherapy for human solid tumors other than colorectal

C Focan1

  • 1Centre Hospitalier Saint-Joseph-Espérance, Liège, Belgium.

In Vivo (Athens, Greece)
|November 1, 1995
PubMed
Summary

Chronobiological treatments improve cancer therapy by increasing drug intensity, reducing toxicity, and enhancing patient survival. This approach shows promise for ovarian, lung, renal, pancreas, breast, and aerodigestive tract cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Auto-Immune Pancreatitis with Pseudo-Tumoral Mass Induced by Pembrolizumab in a Woman suffering from Metastatic Urothelial Carcinoma: Case Report and Literature survey.

Acta gastro-enterologica Belgica·2026
Same author

Stauffer syndrome : a rare paraneoplastic complication of renal cell carcinoma to be kept in mind. Case report and literature survey.

Acta gastro-enterologica Belgica·2024
Same author

Patient management after primary rectal cancer diagnosis. Special focus on surgical treatment for non-metastatic disease.

Acta chirurgica Belgica·2023
Same author

[Demons-Meigs syndrome secondary to an ovarian Brenner tumour. Case report and literature survey].

Revue medicale de Liege·2018
Same author

Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2018
Same author

Adherence to geriatric assessment-based recommendations in older patients with cancer: a multicenter prospective cohort study in Belgium.

Annals of oncology : official journal of the European Society for Medical Oncology·2018

Area of Science:

  • Oncology
  • Chronobiology
  • Pharmacology

Background:

  • Chronobiology applies time-based principles to medical treatments.
  • Solid tumors present significant challenges in treatment efficacy and toxicity.
  • Optimizing drug delivery timing is crucial for improving cancer therapy.

Purpose of the Study:

  • To review available data on chronobiological approaches in treating human solid tumors.
  • To assess the impact of chronobiological treatments on therapeutic index and patient outcomes.
  • To identify specific cancer types where chronotherapy has shown efficacy.

Main Methods:

  • Systematic review of published clinical trials and data.
  • Analysis of treatment protocols involving timed drug administration.
  • Evaluation of therapeutic index, toxicity, tumor response, and survival rates.

Main Results:

  • Chronobiological treatments generally improve the therapeutic index.
  • Increased overall drug dose intensities were observed with reduced toxicity.
  • Excellent tumor response and survival rates were noted in treated patients.

Conclusions:

  • Chronobiological strategies enhance cancer treatment efficacy and tolerability.
  • Timed drug delivery is a valuable approach for managing solid tumors.
  • This method shows significant benefits for ovarian, lung, renal, pancreas, breast, and upper aerodigestive tract carcinomas.

Related Experiment Videos