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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
Published on: May 14, 2016
Chronotherapy for human solid tumors other than colorectal
1Centre Hospitalier Saint-Joseph-Espérance, Liège, Belgium.
Abstract:
Available data regarding the application of chronobiological concepts to the medical treatment of various human solid tumors are reviewed. In the majority of reported trials, an improvement of therapeutic index has been observed with an increase in overall drug dose intensities, despite reduced overall toxicity and an excellent level of tumor response and survival. This assessment was obvious for ovarian, lung (non small cell), renal cell, pancreas, breast and upper aerodigestive tract carcinomas.
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