Hepatic resections after chronotherapy: surgical aspects

Hepatic resection has always been recommended for the treatment of metastatic disease in selected patients. Surgeons have had modified their approach and timing of surgery since the introduction of chemotherapy. The authors report their experiences since the introduction of chronochemotherapy. From 1990 up to 1994, 9 hepatic resections were performed for metastatic colorectal carcinoma. During the same period, 11 arterial accesses were implanted for diffused hepatic disease. Of the 9 resected patients, 5 are still alive with a mean follow-up of 17.7 months with no signs of recurrent disease.