Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Titanium aneurysm clips: Part I--Mechanical, radiological, and biocompatibility testing

M T Lawton1, J C Ho, W D Bichard

  • 1Division of Neurological Surgery, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.

Neurosurgery
|June 1, 1996
PubMed
Summary

New titanium aneurysm clips offer superior imaging quality with minimal artifact compared to traditional cobalt alloy clips. These titanium clips are mechanically equivalent, biocompatible, and corrosion-resistant for enhanced patient care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emergency Department Visits for Chronic Subdural Hematomas within 30 Days after Surgical Evacuation with and without Middle Meningeal Artery Embolization.

AJNR. American journal of neuroradiology·2022
Same author

Prenatal exposure to nickel and atopic dermatitis at age 3 years: a birth cohort study with cytokine profiles.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Resveratrol enhanced chemosensitivity by reversing macrophage polarization in breast cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2021
Same author

Utility of modified Rankin Scale for brain vascular malformations in hereditary hemorrhagic telangiectasia.

Orphanet journal of rare diseases·2021
Same author

Paediatric glaucoma in Hong Kong: a multicentre retrospective analysis of epidemiology, presentation, clinical interventions, and outcomes.

Hong Kong medical journal = Xianggang yi xue za zhi·2021
Same author

Predictors of mortality in patients with hereditary hemorrhagic telangiectasia.

Orphanet journal of rare diseases·2021

Area of Science:

  • Biomaterials Science
  • Neurosurgery
  • Medical Imaging

Background:

  • Aneurysm clips commonly use cobalt-based alloys, causing significant artifact in magnetic resonance (MR) imaging.
  • This artifact degrades the quality of postoperative MR images, potentially impacting patient diagnosis and monitoring.

Purpose of the Study:

  • To evaluate the mechanical properties, biocompatibility, and imaging characteristics of novel pure titanium aneurysm clips.
  • To compare the performance of titanium clips against conventional cobalt alloy clips in reducing imaging artifact.

Main Methods:

  • In vitro mechanical testing, including closing force measurements and fatigue analysis (>20 million cycles).
  • In vivo biocompatibility assessment in rabbits (1-6 months implantation).
  • Radiological evaluation in greyhound dogs comparing artifact from titanium and cobalt-chrome alloy clips on CT and MR imaging.

Related Experiment Videos

Main Results:

  • Titanium clips demonstrated consistent closing forces (151.6–181.8 g) unaffected by sterilization or stress.
  • Mechanical fatigue testing showed no clip opening or reduction in closing force.
  • Mild gliosis was observed, comparable to cobalt alloy clips, with no evidence of corrosion in titanium implants.
  • Titanium clips produced 2-3 times less artifact on CT and MR imaging compared to cobalt-chrome alloy clips.

Conclusions:

  • Titanium aneurysm clips are mechanically equivalent to conventional clips, exhibiting excellent biocompatibility and corrosion resistance.
  • These titanium clips offer superior imaging characteristics, significantly reducing CT and MR imaging artifact.
  • The improved imaging quality allows for better resolution of anatomical structures, enhancing postoperative assessment.