Related Experiment Videos
Cyanoacrylate tissue adhesive in blepharoplasty
A Veloudios1, V Kratky, J G Heathcote
1Department of Surgery, Eye Institute, Cooper Hospital, Camden, New Jersey 08103, USA.
Ophthalmic Plastic and Reconstructive Surgery
|June 1, 1996
Summary
Butyl 2-cyanoacrylate (Histoacryl) offers comparable wound strength to traditional sutures in blepharoplasty initially. However, glued incisions showed significantly greater tensile strength at 9 weeks, with no adverse effects on healing.
Area of Science:
- Plastic Surgery
- Wound Healing
- Biomaterials
Background:
- Blepharoplasty commonly utilizes sutures for skin closure.
- Butyl 2-cyanoacrylate (Histoacryl) is a tissue adhesive with potential applications in surgical closure.
- Evaluating novel closure methods is crucial for optimizing surgical outcomes.
Purpose of the Study:
- To assess the efficacy of butyl 2-cyanoacrylate (Histoacryl) compared to 6.0 nylon sutures for blepharoplasty skin closure.
- To compare the tensile strength and histopathologic outcomes of wounds closed by Histoacryl versus sutures.
Main Methods:
- Animal study involving seven pigs undergoing bilateral upper and lower lid blepharoplasty.
- Skin incisions were closed using either Histoacryl or 6.0 nylon sutures.
- Wound tensile strength and histopathology were evaluated at 1, 2, 4, and 9 weeks postoperatively.
Main Results:
- No significant difference in bond strength between Histoacryl and sutures at 1, 2, and 4 weeks.
- Significantly greater tensile strength for Histoacryl-closed incisions at the 9-week interval (p < 0.05).
- Histopathologic analysis revealed no deleterious effects on cutaneous wound healing with Histoacryl.
Conclusions:
- Butyl 2-cyanoacrylate (Histoacryl) is a viable alternative for blepharoplasty skin closure.
- Histoacryl demonstrates comparable early wound healing to sutures, with superior tensile strength at later time points.
- Tissue adhesive use in blepharoplasty does not impede the overall cutaneous healing process.