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Published on: March 8, 2012
Identification of an epitope for T-cells correlated with antibody response to hepatitis B surface antigen in
W P Min1, N Kamikawaji, M Mineta
1Department of Genetics, Medical Institute of Bioregulation, Fukuoka, Japan.
Abstract:
Two antigenic T-cell epitopes of HBsAg, designated HBs 16-31 and HBs 81-99, were identified using synthetic peptides and HBsAg-specific T-cell lines. HBs 16-31 was recognized by five HBsAg-specific T-cell lines from vaccinees with both high and low antibody titers, whereas HBs 81-99 was recognized by two T-cell lines derived from vaccinees with high antibody titers. The antibody titer against HBsAg was correlated significantly with the proliferation of vaccinee's PBLs in response to HBs 81-99 (r = 0.47) but not to HBs 16-31, suggesting that HBs 81-99 plays a critical role in anti-HBs antibody production in humans vaccinated with HBsAg.
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