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Fixed exanthema due to paracetamol

M Gómez Martínez1, C Fernández de Miguel, A Domínguez Lázaro

  • 1Allergy Service, Clínica Puerta de Hierro, Madrid, Spain.

Journal of Investigational Allergology & Clinical Immunology
|March 1, 1996
PubMed
Summary

Fixed exanthema, a drug reaction, commonly affects skin and mucous membranes. This case highlights paracetamol as a potential cause in a 36-year-old man.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Clinical Medicine

Background:

  • Fixed exanthema constitutes 10% of adverse drug reactions.
  • Drug-induced causes account for up to 80% of fixed exanthema cases.

Observation:

  • Lesions typically manifest on genitals, perianal region, limbs, and oral mucosa.
  • A 36-year-old male patient presented with fixed exanthema.

Findings:

  • The patient developed fixed exanthema subsequent to paracetamol administration.
  • Paracetamol is identified as the causative agent in this specific case.

Implications:

  • This case underscores the importance of considering paracetamol in the differential diagnosis of fixed exanthema.

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  • Awareness of paracetamol-induced fixed exanthema is crucial for clinicians managing adverse drug reactions.