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Related Experiment Videos

Emx and Otx gene expression in the developing mouse brain

E Boncinelli1, M Gulisano, F Spada

  • 1DIBIT, Istituto Scientifico H.S. Raffaele, Milano, Italy.

Ciba Foundation Symposium
|January 1, 1995
PubMed
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Homeobox genes Emx1, Emx2, Otx1, and Otx2 show nested expression patterns in the embryonic rostral brain. Otx2 expression recedes from the cerebral cortex, while Emx1, Emx2, and Otx1 persist.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Homeobox genes play crucial roles in embryonic development, particularly in patterning the central nervous system.
  • Specific homeobox genes like Emx1, Emx2, Otx1, and Otx2 are known to be involved in early brain formation.

Purpose of the Study:

  • To characterize the spatial and temporal expression patterns of Emx1, Emx2, Otx1, and Otx2 in the developing embryonic brain.
  • To elucidate the hierarchical relationships between the expression domains of these homeobox genes.

Main Methods:

  • In situ hybridization was used to visualize gene expression in embryonic brain sections.
  • Detailed analysis of gene expression domains at different embryonic stages (E10 and E10.75).

Main Results:

Related Experiment Videos

  • At E10, Emx1, Emx2, Otx1, and Otx2 exhibit nested expression domains within the rostral embryonic brain.
  • Otx2 expression domain encompasses Otx1, Emx1, and Emx2; Otx1 domain contains Emx1 and Emx2; Emx2 domain contains Emx1.
  • Starting at E10.75, Otx2 expression diminishes in the presumptive cerebral cortex, while Emx1, Emx2, and Otx1 expression continues until late gestation.
  • Emx2 shows exclusive expression in the germinal ventricular zone of the developing cerebral cortex.

Conclusions:

  • The nested expression patterns of Emx1, Emx2, Otx1, and Otx2 suggest a coordinated role in rostral brain development.
  • The dynamic regulation of Otx2 expression in the cerebral cortex, contrasting with the sustained expression of Emx1, Emx2, and Otx1, highlights distinct developmental contributions.