Related Experiment Videos
Gene therapy of cancer
K D Robinson1, E Abernathy, K J Conrad
1Cancer Control/Community Outreach Services, University of Pittsburgh Cancer Institute, PA 15213, USA.
Objective:
To provide a review of the basic concepts and terminology of human genetics, the clinical application and risks of gene therapy, and ethical and societal issues.
Data Sources:
Review articles, research studies, and book chapters related to genetics and human gene therapy.
Conclusions:
The genetic changes that play a role in the development of cancer have begun to be elucidated, and these discoveries have led to strategies to destroy cancers by correcting genetic defects or manipulating genes to induce tumoricidal activities. Gene therapy is a novel investigational intervention that is constantly evolving.
Implications For Nursing Practice:
Oncology nurses will need an increased understanding of cellular biology, genetics, and genetics engineering. Major considerations for nursing practice include patient and family education, informed consent, side effects, and ethical and societal issues.