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Gaseous second messengers in vertebrate olfaction

M C Broillet1, S Firestein

  • 1Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Journal of Neurobiology
|May 1, 1996
PubMed
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Nitric oxide (NO) and carbon monoxide (CO) act as crucial messengers in the nervous system, particularly within the olfactory system. Their roles in signal transduction, development, and regeneration are increasingly recognized, though not fully understood.

Area of Science:

  • Neuroscience
  • Olfactory System Biology
  • Cellular Signaling

Background:

  • Gaseous monoxides, including nitric oxide (NO) and carbon monoxide (CO), are recognized as vital signaling molecules in the nervous system.
  • Enzymes responsible for NO and CO production are highly expressed in the olfactory system's epithelium and bulbs.

Purpose of the Study:

  • To review emerging data on the physiological roles of NO and CO in the olfactory system.
  • To highlight recent findings regarding NO and CO in signal transduction, development, and regeneration.

Main Methods:

  • Literature review of recent research on gaseous monoxides in the olfactory system.
  • Analysis of studies investigating NO and CO pathways and interactions.

Main Results:

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  • NO and CO play integral roles in olfactory system functioning.
  • Evidence suggests NO and CO modulate the olfactory transduction process.
  • Potential roles in olfactory system development and regeneration are indicated.

Conclusions:

  • NO and CO are essential components of the olfactory system's function.
  • Further research is needed to fully elucidate the diverse roles of NO and CO in olfaction.