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An iridoid glucoside from dipsacus asperoides
Phytochemistry
|May 1, 1996
Summary
A novel iridoid glucoside, loganic acid-6'-O-beta-D-glucoside, was identified in Dipsacus asperoides roots. This compound
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Organic Chemistry
Background:
- Dipsacus asperoides is a plant with a history of traditional medicinal use.
- The isolation of novel compounds from plant sources is crucial for discovering new therapeutic agents.
Purpose of the Study:
- To isolate and characterize a new iridoid glucoside from Dipsacus asperoides.
- To elucidate the chemical structure of the newly discovered compound.
Main Methods:
- Defatting of Dipsacus asperoides root material.
- Isolation of the target compound using chromatographic techniques.
- Structure elucidation via comprehensive spectroscopic analysis (e.g., NMR, MS).
Main Results:
- A new iridoid glucoside, named loganic acid-6 -O-beta-D-glucoside, was successfully isolated.
- The precise stereochemistry and structure were determined to be 1S-(1 alpha,4a alpha,6 alpha,7 alpha,7a alpha)-1-[(6-O-beta-D- glucopyranosyl-beta-D-glucopyranosyl)oxyl]1,4a,5,6,7,7a-hexahydro-6-hydr oxy-7- methyl-cyclopenta[c]pyran-4-carboxylic acid.
Conclusions:
- The study reports the first isolation and structural determination of loganic acid-6 -O-beta-D-glucoside.
- This finding contributes to the phytochemical knowledge of Dipsacus asperoides and may inform future research into its bioactivity.