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Apolipoprotein E is increased in aged rat kidney

S C Chou1, B Cheng, T R Hornick

  • 1Department of Medicine Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

Biochemistry and Molecular Biology International
|April 1, 1996
PubMed
Summary
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Apolipoprotein E (apoE) levels increase in aged rats, particularly in the kidneys. This selective increase in kidney apoE may be significant for aging processes and warrants further investigation.

Area of Science:

  • Biochemistry
  • Gerontology
  • Physiology

Background:

  • Apolipoprotein E (apoE) is implicated in human age-related disorders and longevity.
  • Understanding apoE's role in aging requires animal models to study organ-specific changes.

Purpose of the Study:

  • To investigate age-related differences in apolipoprotein E concentrations across various organs in a rat model.
  • To determine if apoE levels change with age in plasma and specific tissues like the brain, heart, kidney, liver, and spleen.

Main Methods:

  • Quantification of immunoreactive apolipoprotein E (apoE) in plasma and tissue homogenates.
  • Comparison of apoE levels between aged rats (24-25 months) and younger control rats (6-8 months).

Main Results:

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  • Plasma apoE concentrations were 70% higher in aged rats compared to young rats (P < 0.01).
  • No significant age-related differences in apoE levels were observed in the brain, heart, liver, or spleen.
  • Kidney apoE concentrations were markedly elevated by 490% in aged rats versus young rats (P < 0.01).

Conclusions:

  • Age-related changes in organ apoE concentrations are heterogeneous in rats.
  • The selective and substantial increase in kidney apoE in aged rats suggests potential physiological significance.
  • Further research is needed to elucidate the functional implications of increased kidney apoE during aging.