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Biologic markers of arthritis
D M Scher1, E S Stolerman, P E Di Cesare
1Department of Orthopaedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA.
American Journal of Orthopedics (Belle Mead, N.J.)
|April 1, 1996
Summary
Biologic markers in joint fluid, serum, or urine can detect early arthritis and track disease. Research explores extracellular matrix, enzymes, cytokines, and nitric oxide for diagnosis and treatment prediction.
Area of Science:
- Biochemistry
- Immunology
- Rheumatology
Background:
- Arthritis involves degenerative joint disease.
- Biologic markers offer potential for sensitive and specific detection of subclinical joint disease.
Purpose of the Study:
- To review current research on biologic markers for arthritis.
- To discuss potential clinical applications of these markers.
Main Methods:
- Investigation of four major categories of potential biologic markers: extracellular matrix constituents, degradative proteolytic enzymes, cytokines, and nitric oxide.
- Review of current research and emerging data in the field.
Main Results:
- Biologic markers can be detected in synovial fluid, serum, or urine.
- These markers show potential for early diagnosis, disease monitoring, and treatment response prediction.
- Key areas of investigation include extracellular matrix components, proteolytic enzymes, cytokines, and nitric oxide.
Conclusions:
- Biologic markers are promising tools for managing arthritis.
- Further research is needed to translate findings into widespread clinical practice.
- These markers could revolutionize arthritis diagnosis and patient management.