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Related Experiment Videos

Relationship between memory and fear: developmental and pharmacological studies

M V Pletnikov1, Z I Storozheva, V V Sherstnev

  • 1P. K. Anokhin Institute of Normal Physiology, Moscow, Russia.

Pharmacology, Biochemistry, and Behavior
|May 1, 1996
PubMed
Summary

Young rats cannot habituate to acoustic startle responses (ASR) long-term, but all ages show fear conditioning. Diazepam affects freezing and ASR habituation differently, suggesting dissociations in fear and memory processing.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Developmental Psychology

Background:

  • Habituation and fear conditioning are crucial adaptive behaviors.
  • Understanding their developmental trajectory and pharmacological modulation is key to comprehending fear and memory processes.

Purpose of the Study:

  • To investigate age-related differences in acoustic startle response (ASR) habituation and fear conditioning in rats.
  • To examine the effects of diazepam on these behaviors in adult rats to explore fear and memory interactions.

Main Methods:

  • Simultaneous assessment of acoustic startle response (ASR) habituation and freezing responses in rats across different ages.
  • Administration of diazepam (1.2 and 2.5 mg/kg) to adult rats to evaluate its impact on fear and memory-related behaviors.

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Main Results:

  • Rats younger than 30 days failed to exhibit long-term ASR habituation.
  • Fear conditioning increased freezing responses in all age groups.
  • Diazepam suppressed ASR amplitude over trials and increased initial freezing, but decreased fear-conditioned freezing.

Conclusions:

  • Developmental dissociation exists between ASR habituation and fear conditioning.
  • Diazepam differentially impacts fear and memory components, suggesting distinct neural underpinnings.
  • These findings highlight dissociations in behavioral responses to aversive cues.