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The prospects for developing a vaccine against Staphylococcus aureus
1Dept of Medicine, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. jclee@warren.med.harvard.edu
Trends in Microbiology
|April 1, 1996
Abstract:
Staphylococcus aureus is an important bacterial pathogen with multiple virulence factors. The prevalence of antibiotic resistance among clinical isolates means that new vaccine strategies to prevent staphylococcal infections are needed. An ideal vaccine would induce antibodies to prevent bacterial adherence, promote opsonophagocytic killing by leukocytes and neutralize toxic secreted proteins.