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Behavioral interactions between naloxone and dopamine agonists

R A Harris, D Snell, H H Loh

    European Journal of Pharmacology
    |June 1, 1977
    PubMed
    Summary
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    Low doses of apomorphine and ET-495, but not clonidine, decreased rat responding. Naloxone enhanced these effects, suggesting potential dopaminergic inhibition by naloxone.

    Area of Science:

    • Neuropharmacology
    • Behavioral pharmacology

    Background:

    • Dopamine receptor agonists like apomorphine and ET-495, and alpha-2 adrenergic agonists like clonidine, are known to affect behavior.
    • Naloxone, an opioid antagonist, has complex interactions with other neurotransmitter systems.

    Purpose of the Study:

    • To investigate the effects of apomorphine, ET-495, and clonidine on fixed-interval responding in rats.
    • To examine the interactions between these drugs and naloxone.

    Main Methods:

    • Rats were trained on a fixed-interval schedule of food reinforcement.
    • The effects of apomorphine, ET-495, clonidine, and naloxone, alone and in combination, on response rates were measured.

    Main Results:

    • Low doses of apomorphine (0.03–0.3 mg/kg), ET-495 (0.3–1.0 mg/kg), and clonidine (0.03–0.3 mg/kg) decreased response rates.

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  • Naloxone (3 mg/kg) potentiated the rate-decreasing effects of apomorphine and ET-495 but did not affect clonidine's action.

    • Conclusions:

    • The rate-decreasing effects of low-dose apomorphine and ET-495 may involve presynaptic inhibition of dopamine neurons.
    • Naloxone may also inhibit dopaminergic activity under specific conditions.