Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Massive ovarian oedema

F F Nogales1, L Martin-Sances, E Mendoza-Garcia

  • 1Department of Pathology, University Hospital, Granada, Spain.

Histopathology
|March 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different Mutational Profiles of Subcutaneous Panniculitis-like T-cell Lymphoma and Lupus Panniculitis: An Additional Case Series.

Actas dermo-sifiliograficas·2024
Same author

Different Mutational Profiles of Subcutaneous Panniculitis-like T-cell Lymphoma and Lupus Panniculitis: An Additional Case Series.

Actas dermo-sifiliograficas·2024
Same author

Real-life analysis on safety and efficacy of asciminib for ponatinib pretreated patients with chronic myeloid leukemia.

Annals of hematology·2022
Same author

Store-independent Orai1-mediated Ca<sup>2+</sup> entry and cancer.

Cell calcium·2019
Same author

Position of the Spanish Menopause Society regarding the management of perimenopause.

Maturitas·2013
Same author

Estrogen-related genes and postmenopausal osteoporosis risk.

Climacteric : the journal of the International Menopause Society·2012
Same journal

Myxoid neoplasms with MAP3K kinase fusion: a study of 39 cases.

Histopathology·2026
Same journal

TROP2 immunoreactivity in pulmonary large cell neuroendocrine carcinoma.

Histopathology·2026
Same journal

Malignant adenomyoepithelioma of the breast: seven cases illustrating morphological diversity and diagnostic challenges.

Histopathology·2026
Same journal

A CRX-positive RB1-deficient bone tumour with a retinoblastoma-like DNA methylation profile.

Histopathology·2026
Same journal

Perivascular epithelioid cell tumours of the genitourinary tract: clinicopathological features and molecular landscape.

Histopathology·2026
Same journal

Navigating diagnostic challenges in low-grade spindle cell lesions of the breast: a retrospective review.

Histopathology·2026
See all related articles

Massive ovarian edema, often presenting as an acute abdomen in young women, is linked to ovarian torsion and ischemia. This condition involves stromal cell transformation, not proliferation, and may explain associated hormonal symptoms.

Area of Science:

  • Gynecologic pathology
  • Reproductive endocrinology
  • Surgical pathology

Background:

  • Massive ovarian edema (MOE) is a rare condition, often presenting with acute abdominal pain.
  • Hormonal symptoms like virilism and precocious pseudopuberty can occur in MOE.
  • Previous studies have yielded variable diagnostic accuracy for ultrasonography in MOE.

Observation:

  • This study analyzed 18 cases of MOE, with a mean patient age of 26 years.
  • Ovarian torsion was a frequent finding (14/18 cases), with 72% occurring in the right ovary.
  • Immunohistochemistry revealed low Ki-67 proliferation but high PCNA indices, suggesting repair after ischemia.

Findings:

  • Stromal cells in MOE showed positive alpha-actin, indicating myofibroblastic transformation.

Related Experiment Videos

  • PCNA positivity is hypothesized to be related to nuclear repair following ischemic events.
  • Estrogen and progesterone receptors were present in stromal cells, potentially explaining hormonal symptoms.

    • Implications:

    • MOE is considered a reactive, non-proliferative stromal cell response to torsion and ischemia, rather than a proliferative process.
    • The findings suggest a mechanism for the hormonal disturbances observed in MOE.
    • Understanding the pathogenesis of MOE may guide future diagnostic and therapeutic strategies.