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Infectious etiologies of rhabdomyolysis: three case reports and review
1Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Abstract:
Rhabdomyolysis can be precipitated by trauma, ischemia, metabolic defects, electrolyte abnormalities, drugs, and a wide variety of infectious diseases. At our institution, recent cases of rhabdomyolysis induced by influenza prompted us to review the infectious etiologies of this entity. In addition, a thorough literature search revealed numerous case reports but no general review on this subject. This study describes representative recent cases from our institution and details the wide variety of infections that can cause muscle damage. The pathophysiological mechanisms, muscle histology, and correlation with renal dysfunction are also discussed.
Insights
Infectious diseases, including influenza, can cause rhabdomyolysis, a muscle breakdown condition. This review details various infections leading to muscle damage and associated kidney problems.
Area of Science:
- Infectious Diseases
- Neurology
- Nephrology
Background:
- Rhabdomyolysis is a clinical syndrome characterized by muscle breakdown.
- Causes include trauma, ischemia, metabolic defects, drugs, and infections.
Observation:
- Recent cases of rhabdomyolysis induced by influenza at our institution prompted this review.
- A literature search revealed numerous case reports but no general review on infectious etiologies.
Findings:
- This study details a wide variety of infections that can cause rhabdomyolysis.
- Representative cases from our institution are described.
- Pathophysiological mechanisms, muscle histology, and renal dysfunction correlations are discussed.
Implications:
- Highlights the diverse range of infectious agents capable of inducing rhabdomyolysis.
- Emphasizes the importance of considering infections in the differential diagnosis of rhabdomyolysis.
- Provides a comprehensive overview for clinicians managing patients with rhabdomyolysis and concurrent infections.