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[Primary vesico-ureteral reflux. Current data and perspectives]

H Lottmann, Y Aigrain

    Presse Medicale (Paris, France : 1983)
    |February 10, 1996
    PubMed
    Summary
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    Early screening for primary vesicoureteral reflux (VUR) in at-risk infants and children is crucial. Prompt diagnosis and management of VUR and bladder dysfunction can prevent severe kidney damage.

    Area of Science:

    • Pediatric Nephrology
    • Urology

    Background:

    • Primary vesicoureteral reflux (VUR) is a common condition that can lead to renal dysplasia and scarring, often detected too late after urinary tract infections.
    • Currently, no biological screening test exists for VUR, necessitating alternative diagnostic approaches for early detection.

    Discussion:

    • Screening newborns with antenatal pyelocaliceal dilation and siblings of treated VUR patients with cystography is recommended.
    • Identifying and treating associated bladder dysfunction is essential for managing VUR effectively.
    • VUR presents differently across age groups and sexes, with antenatal cases more common in males and school-age girls often showing post-infectious scarring and bladder issues.

    Key Insights:

    • Early diagnosis of VUR is critical to prevent irreversible renal parenchymal damage.

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  • Targeted screening of high-risk populations, including those with antenatal findings and family history, is vital.
  • Integrated management of VUR, infection prevention, and bladder dysfunction is key to preserving kidney health.

    • Outlook:

    • Developing a biological screening test for VUR would significantly improve early detection rates.
    • Continued research into the diverse clinical presentations of VUR will refine diagnostic and management strategies.
    • Public health initiatives focusing on early VUR detection and management can reduce long-term renal morbidity.