[Hormone concentrations in thyroid gland tissue and plasma in autonomous thyroid adenomas with and without...

The thyroid hormone concentrations of T2, T3 (and the inactive R-T3) were determined in thyroid tissue of 20 patients with autonomous adenomas. High concentrations were found in scintigrafically decompensated adenomas without preoperative thyrostatic treatment. Decompensated adenomas after thyrostatic treatment, compersated adenomas and a group of 9 euthyroid goiters showed no difference in tissue-concentrations of T4 and T3. The amount of tissue-R-T3 seems to be lowered in autonomy. The plasma-concentration of T3, which was intraoperatively elevated in the venous effluent from decompensated adenomas without thyrostatic treatment, was significantly lower in the blood draining decompensated adenomas after thyrostatic treatment as well as compensated adenomas.