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Progressive supranuclear palsy presenting with psychiatric features

H F Chiu, S W Li

    The British Journal of Clinical Practice
    |January 1, 1996
    PubMed
    Summary
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    Early diagnosis of progressive supranuclear palsy (PSP) is challenging, as psychiatric symptoms often appear first. This case shows behavioral issues in PSP may improve with fluoxetine treatment.

    Area of Science:

    • Neurology
    • Psychiatry

    Background:

    • Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease.
    • PSP diagnosis can be difficult, especially in early stages.
    • Psychiatric symptoms are frequently observed in PSP patients.

    Observation:

    • A patient with PSP presented with prominent psychiatric features.
    • Behavioral problems were the initial presenting symptoms.
    • Gaze palsy, a hallmark of PSP, was not the initial symptom.

    Findings:

    • Psychiatric symptoms can precede motor or ocular deficits in PSP.
    • The patient's behavioral issues showed improvement.
    • Fluoxetine was effective in managing the psychiatric symptoms.

    Implications:

    Related Experiment Videos

    • Highlights the importance of considering PSP in patients with unexplained psychiatric changes.
    • Suggests psychiatric symptoms can be an early indicator of PSP.
    • Indicates potential therapeutic benefits of selective serotonin reuptake inhibitors (SSRIs) like fluoxetine for behavioral disturbances in PSP.