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Model building of antibody combining sites
1Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA.
Therapeutic Immunology
|April 1, 1995
Abstract:
The number of high quality crystal structures of antibody fragments available in the Brookhaven Protein Data Bank is rapidly increasing. These structures provide a substantial knowledge base and support model building of novel antibody combining sites. We review some basic principles of antibody structure, describe structure-based modelling procedures, and indicate the strengths and weaknesses of the modelling approach. Applications of antibody models are discussed.