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A metabolic syndrome in diffuse idiopathic skeletal hyperostosis. A controlled study
G Vezyroglou1, A Mitropoulos, C Antoniadis
1Rheumatology Department, Asklepieion Hospital, Voula, Athens, Greece.
The Journal of Rheumatology
|April 1, 1996
Summary
Patients with diffuse idiopathic skeletal hyperostosis (DISH) exhibit a higher prevalence of metabolic disturbances, including diabetes mellitus, dyslipidemia, and hyperuricemia. These conditions may indicate a specific metabolic syndrome associated with DISH.
Area of Science:
- Rheumatology
- Endocrinology
- Metabolic Diseases
Background:
- Diffuse idiopathic skeletal hyperostosis (DISH) is frequently associated with metabolic conditions.
- High incidence of diabetes mellitus (DM), dyslipidemia (DL), and hyperuricemia (HU) observed in DISH patients warrants further investigation.
Purpose of the Study:
- To confirm the association between DISH and common metabolic disturbances.
- To compare the prevalence of metabolic abnormalities in DISH patients versus controls.
Main Methods:
- Comparison of 100 DISH inpatients with 100 age-, sex-, and BMI-matched DISH-free controls.
- Statistical analysis using chi-squared test and 4-fold table analysis to compare metabolic disturbance prevalence.
Main Results:
- 70% of DISH patients had metabolic abnormalities versus 45% in controls (p < 0.0001).
- Combined metabolic features (DM+DL, DM+HU, DM+DL+HU) were significant risk factors for DISH.
- Dyslipidemia showed high prevalence and predictive value in DISH patients.
Conclusions:
- Metabolic disturbances are significantly more prevalent in patients with DISH.
- Further research on ossification progression in relation to metabolic factors is recommended.