Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subacute sclerosing panencephalitis: evaluation with CT and MR

J Brismar1, G G Gascon, K V von Steyern

  • 1Department of Radiology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

AJNR. American Journal of Neuroradiology
|April 1, 1996
PubMed
Summary

Brain imaging in subacute sclerosing panencephalitis (SSPE) shows a consistent pattern of change, but MR findings don't always align with clinical status. This impacts therapy assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus recommendations for diagnosis and treatment of Multiple Sclerosis: 2023 revision of the MENACTRIMS guidelines.

Multiple sclerosis and related disorders·2024
Same author

Clinical and genetic features of Calpainopathies in Saudi Arabia - a descriptive cross-sectional study.

European review for medical and pharmacological sciences·2021
Same author

Consensus recommendations for the diagnosis and treatment of multiple sclerosis: 2019 revisions to the MENACTRIMS guidelines.

Multiple sclerosis and related disorders·2019
Same author

Brain MR Imaging Findings in Woodhouse-Sakati Syndrome.

AJNR. American journal of neuroradiology·2018
Same author

A novel autosomal recessive "Huntington's disease-like" neurodegenerative disorder in a Saudi family.

Saudi medical journal·2016
Same author

Spontaneous internal carotid artery dissection presenting with headache and visual auras: Report of a case.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015

Area of Science:

  • Neurology
  • Radiology
  • Pediatric Neurology

Background:

  • Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disorder.
  • Early diagnosis and monitoring of SSPE are crucial for managing disease progression and evaluating therapeutic interventions.

Purpose of the Study:

  • To analyze the evolution of brain imaging findings using CT and MR in SSPE patients.
  • To establish a baseline for assessing the efficacy of various SSPE therapies based on imaging changes.

Main Methods:

  • Retrospective analysis of 92 MR and 67 CT brain studies from 52 SSPE patients.
  • Correlation of imaging findings with clinical status at different disease stages.

Main Results:

  • MR findings in SSPE follow a predictable pattern, starting with white matter changes and progressing to atrophy.

Related Experiment Videos

  • Clinical status and MR abnormalities showed poor correlation; some patients with mild disease had advanced changes, and vice versa.
  • Therapy response varied, with some patients showing MR improvement and others showing progression despite clinical improvement.

    • Conclusions:

    • The progression of MR abnormalities in SSPE is consistent, but not always correlated with clinical presentation.
    • Careful interpretation of imaging is necessary when evaluating SSPE treatment effects due to discrepancies between clinical and radiological findings.