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The dysmorphic human-mouse homology database (DHMHD): an interactive World-Wide Web resource for gene mapping
C D Evans1, A G Searle, A A Schinzel
1Institute of Child Health, University of London, UK.
Journal of Medical Genetics
|April 1, 1996
Summary
The Dysmorphic Human and Mouse Homology Database (DHMHD) integrates scattered genetic mapping data. This accelerates the isolation of disease-associated genes by enabling rapid cross-referencing of phenotypic and chromosomal homology information.
Area of Science:
- Genetics
- Bioinformatics
- Genomic Medicine
Background:
- Genetic mapping of clinical syndromes relies on identifying specific genomic loci.
- Information for localizing these loci is often dispersed across various publications and databases.
- Existing resources lack efficient methods for integrating diverse data types like homology and chromosomal aberrations.
Purpose of the Study:
- To develop a centralized resource for accelerating genetic mapping of clinical syndromes.
- To facilitate the transition between different types of genetic and phenotypic data.
- To enable rapid cross-referencing through phenotypic and chromosomal homology.
Main Methods:
- Compilation of detailed information from four distinct sources.
- Development of a database system for integrating disparate data.
- Implementation of cross-referencing capabilities based on homology and phenotype.
- Online accessibility via the World-Wide Web.
Main Results:
- The Dysmorphic Human and Mouse Homology Database (DHMHD) prototype has been created.
- DHMHD integrates genetic, phenotypic, and homology data.
- The system allows for rapid data transition and cross-referencing.
Conclusions:
- The DHMHD provides a valuable tool for researchers studying genetic syndromes.
- Integrated data access accelerates the identification of disease-associated genes.
- Online availability enhances the utility and accessibility of this resource for the scientific community.
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