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[Lipid changes of fibrinogen and of platelet aggregation induced by etofibrate]
F A Fonseca1, J P Novazzi, M S Cendoroglo
1Escola Paulista de Medicina-UNIFESP, Sö Paulo.
Purpose:
To evaluate modifications on lipid profile, fibrinogen and platelet aggregation induced by etofibrate.
Methods:
Twenty-one adult patients were studied. They all had primary hyperlipidemia and had already been on the AHA step I diet and placebo. Etofibrate (500mg/day) was administered for 60 days in the active phase, when lipid parameters, fibrinogen and platelet aggregation were measured.
Results:
The % significant reductions were: total cholesterol (-9.50%), LDL-cholesterol (-7.88%), triglycerides (-19.07%), total cholesterol/HDL-cholesterol(-11.90%), LDL-cholesterol/HDL-cholesterol (-10.20%), fibrinogen (-12.79%), platelet aggregation with adrenaline (-24.02%), with ADP 1 mumol (-30.13%), and ADP 3 mumol (-24.51%).
Conclusion:
The beneficial effects of etofibrate were observed not only on the lipid profile but also on the thrombogenic parameters measured by fibrinogen and platelet aggregation.