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Thyroxine-evoked decrease of jejunal lactase activity in adult rats

P Celano, J Jumawan, O Koldovsky

    Gastroenterology
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Thyroid hormones, L-thyroxine and D-thyroxine, significantly reduce jejunal lactase activity in rats. Sucrase activity remained largely unchanged, while acid beta-galactosidase was unaffected by thyroid hormone treatment.

    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Biochemistry

    Background:

    • Thyroid hormones play crucial roles in regulating metabolic processes throughout the body.
    • The impact of thyroid hormones on specific intestinal disaccharidase activities requires further elucidation.

    Purpose of the Study:

    • To investigate the effects of L-thyroxine and D-thyroxine on jejunal lactase, sucrase, and acid beta-galactosidase activities in adult male rats.

    Main Methods:

    • Adult male rats were administered daily injections of L-thyroxine or D-thyroxine at specified dosages.
    • Jejunal enzyme activities (lactase, sucrase, acid beta-galactosidase) were measured at various time points following treatment.

    Main Results:

    • Daily L-thyroxine administration (20 or 200 micrograms/100 g body weight) decreased jejunal lactase activity by 35% within 2-10 days.

    Related Experiment Videos

  • D-thyroxine (200 micrograms/100 g body weight/day for 4 days) also significantly reduced lactase activity.
  • Sucrase activity showed a minor increase (30%) only after 10 days of high-dose L-thyroxine, while acid beta-galactosidase remained unaffected by either hormone.

    • Conclusions:

    • Thyroid hormones, particularly L-thyroxine, exert a significant inhibitory effect on jejunal lactase activity in rats.
    • The observed changes in disaccharidase activity suggest a potential role for thyroid hormones in regulating carbohydrate digestion and absorption.