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Updated: Aug 15, 2026

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
Published on: February 3, 2012
[Atypical forms of the Mayer-Rokitansky-Küster-syndrom (author's transl)]
Abstract:
The internal genitalia in extraordinary forms of müllerian duct malformations were studied in ten patients wit the so called Mayer-Rokitansky-Küster syndrome. Additional abnormalities of the kidneys and the urinary tract were observed in seven cases. Unilateral malformations of the genitalia were not necessarily combined with homolateral malformations of the kidneys and the urinary tract.--Another pathogenetic mechanism seems therefore to exist. There are some clues, that a faulty gonadal differentiation might be responsible, thus inducing regression of the müllerian ducts, as normally seen in male individuals.
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