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Related Experiment Videos

Expression of CD44 isoforms in basal cell carcinomas

H P Baum1, T Schmid, G Schock

  • 1Department of Dermatology, University of Saarland, Homburg/Saar, Germany.

The British Journal of Dermatology
|March 1, 1996
PubMed
Summary

Basal cell carcinomas (BCCs) show low CD44std expression, a hyaluronic acid receptor, potentially blocking metastasis. CD44v6 is present, but CD44v10 is undetectable in these skin tumors.

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Area of Science:

  • Dermatology
  • Oncology
  • Molecular Biology

Background:

  • CD44 isoforms are cell surface glycoproteins involved in cell adhesion and tumor progression.
  • Basal cell carcinoma (BCC) is the most common type of skin cancer, typically with low metastatic potential.

Purpose of the Study:

  • To investigate the expression patterns of CD44std, CD44v6, and CD44v10 in basal cell carcinomas.
  • To correlate CD44 isoform expression with BCC characteristics and metastatic potential.

Main Methods:

  • Immunohistochemical analysis was performed on 42 BCC samples (superficial and nodular types).
  • Expression levels and distribution of CD44std, CD44v6, and CD44v10 were evaluated.

Main Results:

  • CD44std expression was very low in most BCCs, with positive cells mainly in the nest centers.

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  • CD44v6 showed heterogeneous distribution, particularly in peripheral tumor cells, with intensity increasing with nest size in superficial BCCs.
  • CD44v10 was not detectable in any of the studied BCCs.

    • Conclusions:

    • The low expression of CD44std (hyaluronic acid receptor) may contribute to the limited metastatic capacity of BCCs.
    • CD44v6 expression is not associated with the metastatic potential of keratinocyte-derived tumors.