Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microscopic polyangiitis. A systemic vasculitis with a positive P-ANCA

P F Peñas1, J I Porras, J Fraga

  • 1Department of Dermatology, Hospital Universitario de la Princesa, Madrid, Spain.

The British Journal of Dermatology
|March 1, 1996
PubMed
Summary

This case study highlights a rare diagnosis of microscopic polyangiitis in a young girl, characterized by a purpuric rash and kidney damage. Early, aggressive treatment led to a positive clinical response and stabilization of renal function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026
Same author

First Exclusive Reconstruction of the B^{*+}, B^{*0}, and B_{s}^{*0} Mesons and Precise Measurement of Their Masses.

Physical review letters·2026

Area of Science:

  • Nephrology
  • Rheumatology
  • Dermatology

Background:

  • Microscopic polyangiitis (MPA) is a rare systemic vasculitis affecting small blood vessels.
  • MPA typically presents with glomerulonephritis and various extrarenal manifestations.
  • Early diagnosis and aggressive immunosuppressive therapy are crucial for favorable outcomes.

Observation:

  • A young female patient presented with a purpuric rash, fever, eosinophilia, peripheral neuropathy, and progressive renal insufficiency.
  • Skin lesions included vesicles, purpuric macules/papules, nodules, splinter hemorrhages, and facial edema.
  • Renal biopsy revealed focal and segmental necrotizing glomerulonephritis with crescents.

Findings:

  • Anti-neutrophil cytoplasmic antibodies (ANCA) testing was positive for antimyeloperoxidase (MPO) specificity (P-ANCA (MPO)) and negative for PR3 specificity.

Related Experiment Videos

  • The patient fulfilled diagnostic criteria for MPA, including glomerulonephritis and extrarenal small-vessel vasculitis without granulomas or asthma.
  • Treatment with prednisone and cyclophosphamide resulted in clinical improvement, stabilized renal insufficiency, and P-ANCA (MPO) disappearance.

    • Implications:

    • This case underscores the importance of considering MPA in young patients with unexplained renal insufficiency and systemic symptoms.
    • The dermatological manifestations can be diverse, requiring a multidisciplinary approach for diagnosis.
    • Prompt and aggressive immunosuppressive treatment is vital for managing MPA and preventing irreversible organ damage.