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Application of anticancer agent embolism in Miles' operation
1Department of Surgery, Tongji Hospital, Tongji Medical University, Wuhan.
Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
|January 1, 1995
Summary
This study investigated a novel approach for rectal cancer surgery using anticancer agent gelatin sponge embolism and internal iliac artery ligation. The new method significantly reduced complications and relapse rates compared to standard Miles
Area of Science:
- Surgical Oncology
- Gastroenterology
- Vascular Surgery
Background:
- Rectal cancer treatment often involves radical surgery like Miles' operation.
- Minimizing surgical trauma and improving patient outcomes remain key challenges.
Purpose of the Study:
- To evaluate a modified Miles' operation for rectal cancer using anticancer agent gelatin sponge embolism and bilateral internal iliac artery ligation.
- To compare the outcomes of this modified procedure with the standard Miles' operation.
Main Methods:
- Prospective study involving 64 rectal cancer patients undergoing the modified Miles' operation.
- Control group consisted of 24 patients who underwent standard Miles' operation.
- Intervention involved anticancer agent gelatin sponge embolism and ligation of bilateral internal iliac arteries.
Main Results:
- The modified procedure showed statistically significant reductions (P < 0.05) in blood transfusion volume, operation duration, and hospitalization days.
- Lower rates of peritoneal incision infection and cancer relapse were observed in the treated group.
- No significant difference in complication rates was noted between the groups.
Conclusions:
- The modified Miles' operation with gelatin sponge embolism and internal iliac artery ligation is a promising technique for rectal cancer.
- This approach offers potential benefits including reduced surgical trauma, shorter recovery, and improved oncological outcomes.
- Further research is warranted to validate these findings in larger cohorts.