[Erythrocyte immunity and regulating factors in mice infected with Plasmodium berghei ANKA strain]

After seventy-two ICR mice were inoculated with Plasmodium berghei ANKA strain, parasitaemia was revealed in all animals inoculated in two to seven days. During the course the number of malaria parasites increased rapidly from 2.3 +/- 1.3 x 10(3) on d2 to 93.7 +/- 1.8 x 10(3) on d7, the number of erythrocytes increased from 8.2 +/- 0.9 x 10(12)/L on d0 to 11.1 +/- 1.0 x 10(12)/L on d2 and then decreased gradually, reaching 1.9 +/- 0.4 x 10(12)/L on d7, and the number of white blood cells appeared to be fluctuated. Additionally, the rosette rate of erythrocyte=C3b receptor and the rosette rate of erythrocyte-immunocomplex increased on d2 and then decreased gradually to a very low level, suggesting that the erythrocyte immune function reduced in malaria. It is assumed that the reduction in erythrocyte immune function in malaria is attributed to the damage of the erythrocyte membrane in addition to the changes in the function of the erythrocyte immunoregulating factors.