[Clinicopathologic analysis of ependymoma in childhood]

A review of the clinicopathologic features of 23 ependymomas in children was made, of which 17 were male and 6 female, the male:female ratio being 2.8:1. Their average age was 8.8 years. Seven of the 23 ependymomas were supratentorial, 16 were infratentorial. The mean duration of symptoms prior to operation in the two groups was 5.3 and 3 months respectively. Histologically, the tumor could be classified into three types: papillary (or myxopapillary), epithelial and cellular. According to the degree of differentiation, the tumor could be divided into typical ependymoma and anaplastic ependymoma. Immunohistochemically, 17 of the 23 cases were positive for glial fiber acid protein (GFAP) and the remaining 6 cases were negative. The clinicopathologic features of childhood ependymomas, factors influencing prognosis and histologic classification are discussed.