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Basic fibroblast growth factor and PDGF in GI diseases

S Szabo¹, Z Sandor

¹University of California, Irvine, USA.

Bailliere'S Clinical Gastroenterology

|March 1, 1996

Summary

Basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) show potent healing effects on gastrointestinal ulcers and inflammatory lesions. These growth factors accelerate healing without impacting gastric acid secretion.

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Area of Science:

Gastroenterology
Molecular Biology
Pharmacology

Background:

Ulcerative and inflammatory lesions in the GI tract are significant health concerns.
The roles of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in these conditions are under investigation.

Purpose of the Study:

To investigate the pharmacological and pathophysiological roles of bFGF and PDGF in upper and lower GI tract ulcerative and inflammatory lesions.
To evaluate the efficacy of bFGF and PDGF in promoting ulcer healing in animal models.

Main Methods:

Utilized an animal model of chronic cysteamine-induced duodenal ulcers in rats.
Administered bFGF variants (bFGF-w, bFGF-CS23) and PDGF-BB intragastrically.
Conducted biochemical, molecular biological, and immunohistochemical analyses.

Main Results:

Intragastric administration of bFGF and PDGF-BB demonstrated potent healing of chronic duodenal ulcers in rats.
These growth factors were shown to accelerate healing in chronic gastric ulcers, erosive gastritis, and ulcerative colitis.
bFGF and PDGF exhibited no or modest acute gastroprotection despite potent ulcer healing properties.

Conclusions:

bFGF and PDGF play a significant role in the healing of various GI ulcerative and inflammatory conditions.
These growth factors accelerate ulcer healing without affecting gastric acid secretion.
Further research indicates a pathophysiological role for bFGF and PDGF in the natural history of ulcer healing.

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