Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Trefoil peptides

¹In Situ Hybridisation Service, Imperial Cancer Research Fund, London, UK.

Bailliere'S Clinical Gastroenterology

|March 1, 1996

Summary

This summary is machine-generated.

Trefoil peptides are crucial for gastrointestinal mucosal integrity and repair. Research shows these peptides, like intestinal trefoil factor (ITF) and human stomach-specific protein (hSP), promote healing and protect against damage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation.

Oncogene·2012

Same author

Distinct roles for S100a8 in early embryo development and in the maternal deciduum.

Developmental dynamics : an official publication of the American Association of Anatomists·2011

Same author

In Situ Hybridization to Localize mRNAs.

Methods in molecular medicine·2011

Same author

CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer.

Gut·2010

Same author

mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.

The Journal of pathology·2008

Same author

Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen.

Cell proliferation·2008

Same journal

Index.

Bailliere's clinical gastroenterology·2020

Same journal

Home enteral and parenteral nutrition in children.

Bailliere's clinical gastroenterology·1999

Same journal

Nutritional support in malnourished paediatric patients.

Bailliere's clinical gastroenterology·1999

Same journal

Cholestasis and end-stage liver disease.

Bailliere's clinical gastroenterology·1999

Same journal

Cystic fibrosis: nutritional consequences and management.

Bailliere's clinical gastroenterology·1999

Same journal

Pancreatic diseases (excluding cystic fibrosis).

Bailliere's clinical gastroenterology·1999

See all related articles

Area of Science:

Gastroenterology
Molecular Biology
Regenerative Medicine

Background:

Trefoil peptides (pS2, ITF, SP) are vital for gastrointestinal mucosa integrity and repair.
Their expression is altered in ulcerative conditions, with glandular structures expressing these peptides, EGF, and lysozyme.
Goblet and endocrine cells can secrete pS2, aiding local repair efforts.

Purpose of the Study:

To investigate the role of trefoil peptides in gastrointestinal mucosal repair.
To explore the therapeutic potential of recombinant trefoil peptides.
To examine the synergistic effects of trefoil peptides with EGF.

Main Methods:

Expression analysis of trefoil peptides in ulcerative conditions.
Production of recombinant trefoil peptides (rITF, hITF, hSP) in various expression systems.

Related Experiment Videos

In vitro and in vivo studies to assess peptide function and therapeutic efficacy.

Main Results:

Trefoil peptides are upregulated at ulcer margins and in regenerating glands.
Recombinant ITF (rITF), hITF, and hSP exhibit motogenic properties, enhancing epithelial cell migration.
Systemic administration of rITF and hSP protects against indomethacin-induced gastric damage.
Synergistic effects between EGF and rITF were observed in vitro and in vivo.

Conclusions:

Trefoil peptides play a significant role in mucosal healing and protection.
Recombinant trefoil peptides demonstrate therapeutic potential for treating gastrointestinal ulcers.
Combined therapy with EGF and trefoil peptides may offer enhanced ulcer treatment strategies.