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Positive and negative immunomodulation by opioid peptides
L G Roda1, L Bongiorno, E Trani
1Dipartimento di Medicina Sperimentale, Universita degli Studi di Roma, Italy.
International Journal of Immunopharmacology
|January 1, 1996
Summary
Opioid peptides modulate neuroimmune functions through dual immunomodulatory effects. This review focuses on nervous system-to-immune interactions, highlighting similarities with other signaling substances.
Area of Science:
- Neuroimmunology
- Peptide signaling
Background:
- Opioid peptides play a role in neuroimmune system communication.
- Understanding these interactions is crucial for neuropharmacology.
Purpose of the Study:
- To review evidence on neuroimmune functions mediated by opioid peptides.
- To highlight their dual immunomodulatory effects.
Main Methods:
- Literature review of existing evidence.
- Focus on opioid peptide-mediated neuroimmune interactions.
- Inclusion of limited references to other signaling substances for comparison.
Main Results:
- Opioid peptides exhibit dual immunomodulatory effects.
- Neuroimmune interactions may involve similar mechanisms across different signaling substances.
Conclusions:
- Opioid peptides are key mediators of neuroimmune functions.
- Further research into these dual roles is warranted.