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Scandinavian experience with citalopram in the elderly
1University of Göteborg, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Sweden.
International Clinical Psychopharmacology
|March 1, 1996
Summary
Selective serotonin reuptake inhibitors (SSRIs) like citalopram offer a safer alternative for treating depression in the elderly. This SSRI demonstrated significant efficacy and good tolerability in older adults, including those with dementia.
Area of Science:
- Geriatrics
- Psychiatry
- Clinical Pharmacology
Background:
- Depression affects 12-15% of the elderly population.
- Geriatric depression often presents atypically with somatization.
- Tricyclic antidepressants pose toxicity risks for older adults.
Purpose of the Study:
- To evaluate the efficacy and tolerability of citalopram, a selective serotonin reuptake inhibitor (SSRI), in elderly patients with depression.
- To assess citalopram's effectiveness in patients with comorbid dementia and physical illnesses.
Main Methods:
- Two inter-Nordic studies were conducted.
- Efficacy was assessed using the Hamilton Depression Rating Scale.
- Tolerability and drug interactions were monitored.
Main Results:
- Citalopram significantly improved emotional disturbances in patients with dementia.
- A 53% response rate was observed in elderly depressed patients.
- The drug was well tolerated, even in patients with physical illnesses and polypharmacy.
Conclusions:
- Citalopram is an effective and well-tolerated SSRI for treating depression in the elderly.
- Its favorable pharmacokinetic profile makes it a suitable option, minimizing side effects and drug interactions.
- Citalopram shows promise for managing depression in complex geriatric populations.