Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scaling basic toxicokinetic parameters from rat to man

K Bachmann1, D Pardoe, D White

  • 1Department of Pharmacology, University of Toledo, OH 43606, USA.

Environmental Health Perspectives
|April 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editor's quiz: Oesophagogastric fistula: a post-operative complication.

Gut·2007
Same author

Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea.

The European respiratory journal·2007
Same author

Can ultrasound propagate in the joint space of a human knee?

Ultrasound in medicine & biology·2007
Same author

Racial differences in tendon rupture incidence.

International journal of sports medicine·2007
Same author

Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer.

British journal of cancer·2007
Same author

Montelukast in the treatment of HIV associated immune reconstitution disease.

Sexually transmitted infections·2006
Same journal

A New Start.

Environmental health perspectives·2026
Same journal

Time-Varying Exposure to Element Mixtures and Children's Cognition at 5 Years of Age: Findings from the New Hampshire Birth Cohort Study.

Environmental health perspectives·2026
Same journal

Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda.

Environmental health perspectives·2026
Same journal

Comparison of Temperature-Mortality Associations across the Middle East Using Different Exposure Estimation Approaches.

Environmental health perspectives·2026
Same journal

Workflow for Statistical Analysis of Environmental Mixtures.

Environmental health perspectives·2026
Same journal

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.

Environmental health perspectives·2026
See all related articles

Predicting human drug dosage from animal data is crucial for toxicology and therapeutics. This study developed a model using rat data to accurately estimate xenobiotic half-life and volume of distribution in humans.

Area of Science:

  • Pharmacokinetics and Drug Development
  • Toxicology and Risk Assessment
  • Comparative Physiology

Background:

  • Scaling dispositional parameters of xenobiotics from animals to humans is vital for toxicology and predicting human therapeutic doses.
  • Current scaling methods primarily rely on body weight or surface area differences between species.
  • Accurate interspecies scaling is essential for drug development and risk assessment.

Purpose of the Study:

  • To develop a mathematical model for predicting human xenobiotic dispositional parameters (half-life, volume of distribution) using only rat data.
  • To assess the feasibility of a rat-to-human scaling model for pharmacokinetic parameters.
  • To improve the accuracy of predicting human doses for investigational new drugs.

Main Methods:

Related Experiment Videos

  • Utilized a dataset of approximately 100 different xenobiotics.
  • Collected estimates of xenobiotic half-life and volume of distribution in rats.
  • Developed a mathematical model to predict human parameters based on rat data.

    • Main Results:

    • A predictive mathematical model was successfully developed.
    • Human xenobiotic half-life and volume of distribution values were accurately predicted from rat data.
    • The model demonstrated the potential for reliable interspecies scaling.

    Conclusions:

    • Predicting human xenobiotic dispositional parameters from rat data is feasible and accurate.
    • This rat-based model offers a valuable tool for drug development and toxicological risk assessment.
    • The findings support the use of rat models for predicting human pharmacokinetic behavior.