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Related Experiment Videos

Abnormal colonic transit time in untreated celiac sprue

J C Bai1, E Mauriño, C Martínez

  • 1Clinical Service, Hospital de Gastroenterología C, Buenos Aires, Argentina.

Acta Gastroenterologica Latinoamericana
|January 1, 1995
PubMed
Summary

Celiac sprue significantly delays upper gut transit but accelerates colonic transit, particularly in untreated patients. This disordered colonic motility contributes to diarrhea in celiac disease.

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Area of Science:

  • Gastroenterology
  • Digestive Physiology
  • Celiac Disease Pathophysiology

Background:

  • Motility disorders are implicated in celiac sprue diarrhea.
  • The colon's role in celiac sprue transit remains unclear.

Purpose of the Study:

  • To investigate if celiac sprue alters gut transit.
  • To determine if clinical status influences colonic transit.

Main Methods:

  • Prospective study of 25 untreated celiac sprue patients, 15 treated patients, and 15 controls.
  • Measured oro-cecal transit using lactulose breath H2 test.
  • Assessed colonic transit with radiopaque markers.

Main Results:

  • Untreated celiac sprue patients showed significantly delayed oro-cecal transit.

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  • Colonic transit was significantly faster in untreated patients, driven by a subgroup with rapid transit (<18 hours).
  • Faster colonic transit correlated inversely with fecal weight and steatorrhea.

    • Conclusions:

    • Confirms delayed oro-cecal transit in untreated celiac sprue.
    • Provides first evidence of disordered colonic transit contributing to celiac sprue diarrhea.