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Total leucoderma: a rare manifestation of cutaneous chronic graft-versus-host disease
A Nagler1, M A Goldenhersh, F Levi-Schaffer
1Department of Bone Marrow Transplantation, Hebrew University, Jerusalem, Israel.
The British Journal of Dermatology
|April 1, 1996
Abstract:
We describe a 14-year-old boy who developed total leucoderma during the course of chronic graft-versus-host disease, which developed after allogeneic bone marrow transplantation. Skin biopsy and dihydroxy-phenylalanine staining revealed a total absence of melanocytes from the epidermis. Cytotoxic anti-melanocyte antibodies were found in the patient's serum, and this probably explains the development of the leucoderma.