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Related Experiment Videos

Pulmonary function in children with systemic lupus erythematosus

I Cerveri1, F Fanfulla, A Ravelli

  • 1Institute of Respiratory Diseases, University of Pavia, Italy.

Thorax
|April 1, 1996
PubMed
Summary

Children with systemic lupus erythematosus (SLE) showed improved pulmonary function as their disease activity decreased. Early lung function abnormalities did not predict future lung disease progression.

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Area of Science:

  • Pediatric Rheumatology
  • Pulmonology
  • Clinical Medicine

Background:

  • Children with systemic lupus erythematosus (SLE) can exhibit pulmonary function abnormalities without clinical or radiographic signs of lung disease.
  • The relationship between these early pulmonary changes and disease activity or progression remains unclear.

Purpose of the Study:

  • To investigate the association between pulmonary function abnormalities and disease activity in children with SLE over time.
  • To determine if early functional lung deficits predict the development of lung disease in pediatric SLE patients.

Main Methods:

  • Re-evaluated respiratory function (forced vital capacity and single breath gas transfer factor) and disease activity (SLE activity measure - SLAM) in 13 children with SLE after a mean of 4.5 years.
  • Assessed for clinical and radiographic evidence of lung disease at baseline and follow-up.

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Main Results:

  • No patients developed clinical or radiographic evidence of lung disease.
  • A trend toward improvement in forced vital capacity (FVC) and single breath gas transfer factor (TLCO) was observed as SLE activity (SLAM) decreased.
  • Gas transfer factor (TLCO) was more frequently impaired than FVC, and baseline TLCO correlated with disease activity (SLAM score). Changes in TLCO correlated with changes in SLAM, but FVC changes did not.

Conclusions:

  • Decreased SLE activity in children is associated with improved pulmonary function.
  • Early, isolated pulmonary function abnormalities in pediatric SLE do not appear to predict subsequent lung disease development.