Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic immunization

H C Ertl1, Z Q Xiang

  • 1Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA.

Viral Immunology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Genetic immunization using DNA vaccines offers a stable, cost-effective method for long-lasting immunity in animal models. However, potential safety concerns and slow immune response development require further investigation for human application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel chimpanzee adenovirus-vectored respiratory mucosal tuberculosis vaccine: overcoming local anti-human adenovirus immunity for potent TB protection.

Mucosal immunology·2015
Same author

Adenovirus-based vaccines against rhesus lymphocryptovirus EBNA-1 induce expansion of specific CD8+ and CD4+ T cells in persistently infected rhesus macaques.

Journal of virology·2014
Same author

Protection of non-human primates against rabies with an adenovirus recombinant vaccine.

Virology·2014
Same author

Influenza virus specific CD8⁺ T cells exacerbate infection following high dose influenza challenge of aged mice.

BioMed research international·2013
Same author

CD4+ and CD8+ T-cell responses to latent antigen EBNA-1 and lytic antigen BZLF-1 during persistent lymphocryptovirus infection of rhesus macaques.

Journal of virology·2013
Same author

Genetic adjuvants.

Methods in molecular medicine·2011
Same journal

Reovirus Reassortants Reveal Context-Dependent Oncolytic Phenotypes Across Epithelial Cancer Cell Lines.

Viral immunology·2026
Same journal

Syncytia Formation in the Pathogenesis of SARS-CoV-2 Infection: Lessons from Viral Infections.

Viral immunology·2026
Same journal

Screening and Characterization of Nanobody Against the Emerging Dairy Cattle H5N1 Influenza Virus.

Viral immunology·2026
Same journal

Immunoinformatics-Driven Design of a Multiepitope Vaccine for Rustrela Virus-Induced Neurological Diseases: A New Frontier in Encephalitis and Meningoencephalitis Prevention.

Viral immunology·2026
Same journal

Single-Cell Transcriptomic Profiling Reveals Molecular Alterations in the Airway Epithelial Cells of Children with Wheezing Infected by Respiratory Syncytial Virus.

Viral immunology·2026
Same journal

Effect of Pentoxifylline on Inflammatory Markers in COVID-19: A Meta-Analysis of Randomized Controlled Trials.

Viral immunology·2026
See all related articles

Area of Science:

  • Vaccinology
  • Immunology
  • Molecular Biology

Background:

  • Genetic immunization represents a novel approach in vaccinology.
  • DNA vaccines have demonstrated efficacy in inducing protective immunity against infectious diseases in animal models.

Purpose of the Study:

  • To evaluate the efficacy and potential drawbacks of genetic immunization.
  • To explore the immunologic mechanisms underlying DNA vaccine responses.

Main Methods:

  • Utilized animal models to assess immune responses to genetic immunization.
  • Analyzed the advantages and disadvantages of DNA vaccine technology.

Main Results:

  • DNA vaccines are easy to construct, cost-effective for mass production, and highly temperature-stable.

Related Experiment Videos

  • They induce a broad spectrum of long-lasting immune responses, including cytolytic T cell activity.
  • Potential safety concerns include integration into the host cell genome, and slow immune response development limits applicability in certain scenarios like postexposure prophylaxis.

    • Conclusions:

    • Genetic immunization shows promise as an efficacious tool for inducing protective immunity.
    • Further research is needed to address safety concerns and optimize response kinetics for human use.
    • This approach provides valuable insights into primary immune response mechanisms.