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[Present status of cortisone myopathy]
1Service de médecine interne et maladies systémiques, CHU, La Trouhaude, Dijon, France.
La Revue De Medecine Interne
|January 1, 1996
Summary
Steroid myopathy, a side effect of prolonged steroid treatment, impacts muscle protein synthesis. Early detection is challenging, but imaging and exercise may offer preventative benefits.
Area of Science:
- Neurology
- Endocrinology
- Muscle Physiology
Context:
- Prolonged corticosteroid therapy, especially with 9 alpha fluorinated steroids, can lead to steroid myopathy.
- Current diagnostic methods lack pre-symptomatic sensitivity, and muscular biopsy is invasive.
Purpose:
- To review the pathophysiology, clinical presentation, and diagnostic challenges of steroid myopathy.
- To discuss potential diagnostic tools and preventative strategies for steroid myopathy.
Summary:
- Steroid myopathy involves decreased protein synthesis, particularly affecting fast-twitch type IIB muscle fibers and proximal muscles like the quadriceps.
- Low-density scanners and Magnetic Resonance imaging (MNR) show promise for diagnosis, while a cumulative dose of 400 mg may suffice.
- Physical exercise is a potential preventative measure, though specific rehabilitation programs require further investigation in humans.
Impact:
- Highlights the need for improved diagnostic methods for steroid myopathy.
- Suggests physical exercise as a key preventative strategy for patients undergoing long-term steroid treatment.
- Underscores the susceptibility of specific muscle fiber types and muscle groups to steroid-induced damage.