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[Do corticotherapy and hemodilution decrease postoperative inflammation after maxillofacial surgery?]

D Peillon1, J Dubost, C Roche

  • 1Département d'anesthésie-réanimation, centre hospitalier Lyon-Sud, Pierre-Bénite, France.

Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1996
PubMed
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Corticosteroids effectively reduce postoperative inflammation and swelling after maxillofacial surgery. Preoperative acute normovolaemic haemodilution (PANHD) did not show similar benefits in this study.

Area of Science:

  • Maxillofacial Surgery
  • Surgical Inflammation
  • Anesthesiology

Background:

  • Postoperative inflammation is a significant concern following maxillofacial surgery.
  • Effective management strategies are crucial for patient recovery and outcomes.

Purpose of the Study:

  • To evaluate the efficacy of corticosteroids and preoperative acute normovolaemic haemodilution (PANHD) in mitigating postoperative inflammation.
  • To compare the effects of these interventions on facial edema and acute phase protein levels.

Main Methods:

  • A randomized clinical trial involving 32 patients undergoing maxillary osteotomy.
  • Patients were allocated to four groups: PANHD or no PANHD, and corticosteroids or no corticosteroids.
  • Postoperative inflammation was assessed using radiotelemetry for tissue thickness (edema) and plasma acute phase protein measurements.

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Main Results:

  • Corticosteroids significantly reduced postoperative facial edema and acute phase protein levels.
  • PANHD did not demonstrate any significant effect on reducing facial edema or acute phase proteins.
  • No synergistic effect was observed between PANHD and corticosteroids.

Conclusions:

  • Corticosteroids are effective in decreasing postoperative inflammation and edema after maxillofacial surgery.
  • PANHD is not an effective method for reducing postoperative inflammation in this context.
  • Further research may explore alternative or adjunctive methods for inflammation control.