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[Decrease in plasmatic cholinesterase activity in severe bacterial infections: comparison with the decrease observed

Y Blanloeil1, O Delaroche

  • 1Service d'anesthésie et de réanimation chirurgicale, hôpital G-et R-Laennec, Nantes, France.

Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1996
PubMed
Summary

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Plasma cholinesterase activity significantly decreases in patients with severe infections or cirrhosis. This finding is crucial for understanding drug metabolism during critical illness.

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Sepsis Research

Background:

  • The impact of sepsis on plasma cholinesterase (PChE) activity remains unclear.
  • PChE plays a role in the metabolism of various substances, including anesthetic agents.
  • Understanding PChE activity in critical conditions is vital for patient management.

Purpose of the Study:

  • To investigate the influence of severe postoperative infections and liver cirrhosis on plasma cholinesterase activity.
  • To compare PChE levels in infected patients, cirrhotic patients, and healthy controls.

Main Methods:

  • Plasma cholinesterase activity was measured in three groups: healthy surgical orthopaedic patients, patients with severe postoperative infections, and patients with liver cirrhosis (Child-Pugh C).
  • Statistical analysis was performed to compare PChE levels between groups.

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Main Results:

  • Plasma cholinesterase activity was significantly decreased in patients with severe postoperative infections (1,706 +/- 535 Ul.L-1) and liver cirrhosis (1,318 +/- 538 Ul.L-1) compared to healthy controls (4,716 +/- 1,232 Ul.L-1).
  • The reduction in PChE activity was comparable between the infection and cirrhosis groups (P < 0.001).

Conclusions:

  • Severe infections and advanced liver cirrhosis similarly reduce plasma cholinesterase activity.
  • Further research is needed to determine if this decrease affects the biotransformation of anesthetic agents during severe infections.