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Related Experiment Videos

[Stability control of a copper histidinate solution]

V Leclercq1, M Torck, B Guislain

  • 1Pharmacie centrale, CHRU de Lille.

Annales Pharmaceutiques Francaises
|January 1, 1996
PubMed
Summary

Subcutaneous copper histidinate shows promise for Menkes disease treatment. This study confirms the stability of copper (II)-L-histidine complexes, crucial for validating production methods.

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Materials Science

Context:

  • Menkes disease is a rare genetic disorder affecting copper metabolism.
  • Subcutaneous administration of copper compounds is being explored as a therapeutic strategy.
  • Copper histidinate is a potential candidate for Menkes disease treatment.

Purpose:

  • To characterize the complex formation of Copper (II) with L-Histidine in a 1:2 molar ratio.
  • To assess the stability of the Copper (II)-L-Histidine complex under various conditions.
  • To validate production methods for copper histidinate for potential therapeutic use.

Summary:

  • The study successfully controlled the complex formation of Cu (II)-L-Histidine at a 1:2 molar ratio.
  • The stability of the resulting complex was verified under specific determination and validation conditions.
  • This provides foundational data for the reliable production of copper histidinate.

Impact:

  • Establishes critical parameters for the quality control of copper histidinate.
  • Supports the development of stable and effective copper-based therapies for Menkes disease.
  • Contributes to the validation of manufacturing processes for pharmaceutical applications.

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